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Peptides / MOTS-c / United Kingdom

MOTS-c in the United Kingdom

Legal status, what it is, and the listed suppliers in the United Kingdom that list it.

Legal status in the United Kingdom

Not an approved medicine.

As understood at 2026-09-22. Verify with the MHRA.

What MOTS-c is

MOTS-c is a 16-amino-acid peptide encoded not in the cell nucleus but inside the mitochondrial genome, in the 12S rRNA region. It was identified in 2015. It occurs naturally in tissue and in blood, and the reviewed literature reports that circulating levels fall with age. The synthetic version sold by suppliers is a copy of that natural peptide.

Full MOTS-c page: targets and research →

Listed suppliers in the United Kingdom

9 of the 10 suppliers we list in the United Kingdom list MOTS-c. Listed, not endorsed: each row is the supplier’s own stated terms.

Bluewell Peptides United Kingdom All Bluewell products are supplied strictly for laboratory research use only. They are not intended for human consumption, medical use, therapeutic use, diagnostic use, or veterinary use. Imperial Peptides UK United Kingdom In Vitro Research Use Only. Not for human or veterinary consumption. Midshire Labs United Kingdom All Midshire Labs products are sold strictly for research purposes only. They are not intended for human consumption, medical, veterinary, or diagnostic use. Peptides Lab UK United Kingdom Strictly intended for laboratory research use only. Not for human or veterinary consumption. Precision Research UK United Kingdom For laboratory and research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use. Pure Peptides UK United Kingdom All products are for research use only. Research Peptide United Kingdom Supplied strictly for research and laboratory use only and not for human or veterinary consumption. UK Peptides United Kingdom All products are sold exclusively for in-vitro research. They are not for human or veterinary use. XL Peptides United Kingdom All products are exclusively sold for research purposes. They are not intended for human use, therapeutic, diagnostic, or clinical application.

Clinical Research

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
Lee C, Zeng J, Drew BG, et al. (2015). Cell Metabolism. animal cell culture, then mice (age-related and high-fat-diet models of insulin resistance)
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Reynolds JC, Lai RW, Woodhead JST, et al. (2021). Nature Communications. animal young, middle-aged and old mice, plus measurement of MOTS-c in human skeletal muscle and blood after exercise
The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
Kim KH, Son JM, Benayoun BA, Lee C (2018). Cell Metabolism. in-vitro cultured cells under glucose restriction and other metabolic stress
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
Zheng Y, Wei Z, Wang T (2023). Frontiers in Endocrinology. review n/a (narrative review)