Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats
Anisimov VN, Khavinson VK, Morozov VG (2000). Biogerontology.
Summary
Seventy-six five-month-old female rats were divided into two groups and injected with either saline or the dipeptide Glu-Trp (the active component of Thymogen) five times a week for a year, then observed until natural death with tumours examined microscopically. Mean lifespan was similar between groups, but the lifespan of the longest-lived 10% was greater in the treated group, the calculated ageing rate was lower, and total and malignant tumour incidence were about 1.5 to 1.7 times lower. A single rat study from the group that developed the compound.