Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line
Avolio F, Martinotti S, Khavinson VK, et al. (2022). International Journal of Molecular Sciences.
Summary
Tested five short peptides from the Khavinson series (Epitalon, Vilon, Thymogen, the Thymalin complex and Chonluten) on the human THP-1 monocyte cell line. All five altered proliferative signalling, increasing tyrosine phosphorylation of MAP kinases, and all reduced expression of TNF and IL-6 in macrophage-like cells stimulated with bacterial lipopolysaccharide; Chonluten also inhibited TNF production in monocytes. Peptide-treated cells adhered less to activated endothelial cells. The authors interpret the peptides as inducers of TNF tolerance. A single-cell-line study; one author developed the peptides.