Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Baar MP, Brandt RMC, Putavet DA, et al. (2017). Cell.
Summary
The paper that introduced FOXO4-DRI. The authors identified the transcription factor FOXO4 as important for the survival of senescent cells and designed a peptide that disrupts its interaction with p53. In culture, the peptide caused senescent cells, but not normal cells, to undergo apoptosis. In mice it reduced the toxicity of the chemotherapy drug doxorubicin and, in both a fast-ageing strain and naturally aged animals, was associated with improved fitness, fur density and kidney function. A mouse and cell study from the group that developed the peptide.