Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients
Beck DE, Sweeney WB, McCarter MD, Beart R (2014). International Journal of Colorectal Disease.
Summary
The one human trial of ipamorelin in the literature reviewed for this page. Adults having bowel surgery received intravenous ipamorelin or placebo twice daily from the first day after surgery until discharge, testing whether stimulating the ghrelin receptor helps the gut start working again afterwards. The key efficacy measure was the time from the first administration to tolerating a standard solid meal, with safety tracked through adverse events and laboratory tests. A proof-of-concept study in around a hundred patients, not a trial designed to establish effectiveness.