Thymosin Alpha 1 Plus Routine Treatment for the Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Cao A, Feng F, Zhou X (2024). Journal of the College of Physicians and Surgeons Pakistan.
Summary
Pooled 39 randomised trials covering 3,329 patients having an acute flare-up of chronic obstructive pulmonary disease, comparing routine treatment with and without thymosin alpha-1. The pooled results favoured the addition on lung function, blood oxygen and carbon dioxide levels, length of hospital stay and T-cell counts. The authors state that more high-quality randomised trials are needed to confirm the effect. Most of the pooled trials were published in Chinese-language databases, and the review does not report a formal risk-of-bias result in its abstract.