Vasoactive intestinal peptide as a laboratory supplement to clinical activity index in inflammatory bowel disease
Duffy LC, Zielezny MA, Riepenhoff-Talty M, et al. (1989). Digestive Diseases and Sciences.
Summary
Measured circulating VIP by radioimmunoassay in 115 adults with inflammatory bowel disease, studied cross-sectionally and over six months. Plasma VIP was positively associated with clinical disease activity at baseline and follow-up, and roughly doubled during active periods in patients whose disease fluctuated. As a diagnostic marker its sensitivity was about 81% and specificity about 55%. An older observational study of VIP as a marker of disease activity; no peptide was given to patients.