NAD+ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence
Gallagher C, Emmanuel OO (2026). Ageing Research Reviews.
Summary
Reviewing 113 studies, the authors report that in rodents NAD+ augmentation was often associated with metabolic, mitochondrial and inflammatory improvements, varying by model. In humans, oral precursors nicotinamide riboside and nicotinamide mononucleotide reliably raised NAD-related metabolites in blood or cells and were generally well tolerated over weeks to months, but effects on function, metabolism and other healthspan outcomes were mixed and often null. Their key finding for this page: no eligible outcomes trial evaluated intravenous or intramuscular NAD+ itself for anti-ageing or wellness. The evidence base is for precursors taken by mouth, not for NAD+ given by infusion.