Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys
Goncharova ND, Ivanova LG, Oganyan TE, Vengerin AA, Khavinson VK (2015). Advances in Gerontology (Uspekhi Gerontologii).
Summary
Compared pancragen with the sulfonylurea drug glimepiride in nine old female rhesus monkeys, five receiving a ten-day intramuscular course of pancragen and four an oral course of glimepiride. Blood glucose, insulin and C-peptide were measured before, during and after treatment and during glucose tolerance tests. Both treatments lowered basal glucose; pancragen was also associated with normalised insulin and C-peptide levels, whereas glimepiride produced a stronger, delayed glucose-lowering effect and stimulated C-peptide without changing insulin. Very small groups, no placebo arm, Russian-language paper with an English abstract.