Clinical Research

Effects of long-term growth hormone releasing hormone 1-29 in significantly short children

Grunt JA, Schwartz ID, Buchanan C, Howard CP (1995). Acta Paediatrica.

Summary

Seven children who were significantly short but had normal growth hormone levels were treated with GHRH(1-29), with treatment stopped if growth did not improve by a set margin. It was stopped in two children after 12 months and continued in the other five to 24 months. The authors conclude that some children with idiopathic short stature grow well over the first two years of treatment. Seven children, no control group, and a design that drops non-responders, so it shows what happened to those who responded rather than how often a response occurs.