Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog
Ionescu M, Frohman LA (2006). The Journal of Clinical Endocrinology & Metabolism.
Summary
Asked whether a growth hormone-releasing analogue that acts continuously flattens out the body's natural pulses of growth hormone, which are thought to matter for its effects. Healthy men were sampled overnight before and a week after a single injection. Growth hormone secretion increased and the pulsatile pattern was preserved rather than blunted. The paper describes the compound as binding permanently to the body's own albumin after injection, which is what gives it a half-life of about eight days.