A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
Kannt A, Rajagopal S, Kadnur SV, et al. (2018). Scientific Reports.
Summary
Reports a different small-molecule inhibitor of the same enzyme, JBSNF-000088, rather than 5-amino-1MQ itself. In mice made obese on a high-fat diet it reduced body weight, improved insulin sensitivity and normalised glucose tolerance to the level of lean controls; the effects were absent in mice lacking the enzyme, which the authors take as confirmation the compound works through it. In two genetic obesity models the glucose effects were smaller and came without weight loss. Included because it is the strongest specificity evidence for the target, not because it tests the compound sold by suppliers.