Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
Kasian A, Kolomin T, Andreeva L, et al. (2017). Behavioural Neurology.
Summary
Compared selank, diazepam and the two together in rats, with and without chronic unpredictable stress, using the elevated plus maze as the anxiety measure. Given alone, selank was the most effective at reducing the raised anxiety that a course of the test substances itself produced; under chronic stress, the combination of diazepam and selank brought anxiety measures back to pre-stress values. The authors read this as evidence that selank changes how classical benzodiazepines act rather than simply adding to them. A rat behavioural study.