Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus
Khavinson VKh, Gavrisheva NA, Malinin VV, Chefu SG, Trofimov EL (2007). Bulletin of Experimental Biology and Medicine.
Summary
Studied the tetrapeptide pancragen (Lys-Glu-Asp-Trp-NH2) in Wistar rats made diabetic with streptozotocin, measuring blood glucose and the permeability and adhesion of mesenteric capillaries. Oral pancragen was associated with lower blood glucose during treatment; intramuscular pancragen normalised endothelial adhesion but did not change capillary permeability. The authors describe the results as homeostatic and endothelium-protective effects early in diabetes. A short rat study from the developing group; the abstract gives no group sizes.