Pinealon Increases Cell Viability by Suppression of Free Radical Levels and Activating Proliferative Processes
Khavinson V, Ribakova Y, Kulebiakin K, et al. (2011). Rejuvenation Research.
Summary
Exposed cultured cerebellar granule cells, neutrophils and PC12 cells to oxidative stress with and without the tripeptide pinealon (Glu-Asp-Arg). Pinealon was associated with lower accumulation of reactive oxygen species and less necrotic cell death, with a delayed time course of ERK1/2 activation and changes in the cell cycle. Because the antioxidant effect saturated at low concentrations while cell-cycle effects continued at higher ones, the authors propose the peptide may act on the genome directly. A cell study from the group that developed the peptide.