Effects of pancragen on the differentiation of pancreatic cells during their ageing
Khavinson VKh, Durnova AO, Polyakova VO, et al. (2013). Bulletin of Experimental Biology and Medicine.
Summary
Measured expression of transcription factors that drive pancreatic cell differentiation in 'young' and 'aged' pancreatic cell cultures with and without pancragen. Expression of the markers fell with culture ageing; pancragen was associated with higher expression of acinar-cell factors (Pdx1, Ptf1a) and islet-cell factors (Pdx1, Pax6, Pax4, Foxa2, Nkx2.2) in both young and aged cultures. The authors propose this as a mechanism for the anti-diabetic effects they report elsewhere. A cell-culture study; species of the cultures is not stated in the abstract.