EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease
Khavinson V, Linkova N, Kozhevnikova E, Trofimova S (2021). Molecules.
Summary
A review by the developers of the EDR tripeptide (pinealon) collecting cell, animal and small clinical reports on its neuroprotective properties and proposing a mechanism for Alzheimer's disease. The authors summarise reports that the peptide reduces neuronal apoptosis in vitro, interferes with dendritic-spine loss in neuron cultures from Alzheimer's and Huntington's model mice, and alters behaviour in animal studies, and hypothesise that it enters cells and binds histones or RNA to change MAPK/ERK signalling and expression of apoptotic and antioxidant proteins. Authored by the originating group; the mechanism is proposed, not demonstrated.