The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
Khavinson VK, Linkova NS, Chalisova NI, Ivko OM (2021). Biology Bulletin Reviews.
Summary
A narrative review of Thymalin, a calf-thymus polypeptide preparation registered in Russia, and its short-peptide components including the Glu-Trp dipeptide sold as Thymogen. Summarises the authors' account of the preparations' use in immune dysfunction, infection and post-chemotherapy recovery, and proposes mechanisms involving regulation of gene expression, heat-shock proteins, cytokines and cell differentiation. Written by the originating group; the closing suggestion that these peptides may help in COVID-19 is a hypothesis, not a trial result.