The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
Kim KH, Son JM, Benayoun BA, Lee C (2018). Cell Metabolism.
Summary
A mechanism study. The authors showed that MOTS-c moves from the mitochondria into the cell nucleus after metabolic stress, in a way that depends on AMPK, and there influences a broad set of nuclear genes, including genes carrying antioxidant response elements. MOTS-c was found to interact with stress-responsive transcription factors such as NRF2. The authors present this as evidence that the mitochondrial and nuclear genomes each encode factors that regulate the other. Cell work only.