Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
Kolik LG, Nadorova AV, Antipova TA, et al. (2019). Bulletin of Experimental Biology and Medicine.
Summary
Looked at whether selank affects the memory problems that follow long-term alcohol exposure in rats, and at BDNF, a nerve growth factor, in two brain regions. In rats that had drunk ethanol for 30 weeks, selank prevented the memory and attention disturbances that developed during withdrawal, and in unexposed older rats it improved object recognition. It also prevented the ethanol-driven rise in BDNF in the hippocampus and frontal cortex. A rat study; the authors present BDNF regulation as the mechanism.