Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
Kumar P, Liu C, Suliburk J, et al. (2023). The Journals of Gerontology: Series A.
Summary
Tested whether supplying the two building blocks of glutathione, glycine and N-acetylcysteine, corrects the glutathione deficiency seen in older adults. Twenty-four older adults were randomised to the combination or an alanine placebo for 16 weeks, with twelve young adults taking the combination for two weeks as a reference. The authors report improvements in glutathione levels, oxidative stress, mitochondrial function, inflammation, insulin resistance and physical function. Participants took the precursors, not glutathione itself.