Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormone
Neyzi O, Yordam N, Ocal G, et al. (1993). Acta Paediatrica.
Summary
Forty-three children with growth hormone deficiency originating in the hypothalamus were randomly assigned to lower-dose GHRH(1-29), higher-dose GHRH(1-29), or growth hormone itself, for six months. Height velocity increased by at least 2 cm a year in all but two children. The lower-dose group grew least; the higher-dose GHRH group and the growth hormone group were comparable on height velocity, but only the growth hormone group gained height relative to bone age. The study is from the programme that led to the peptide being marketed for paediatric growth hormone deficiency.