Exploring NNMT: from metabolic pathways to therapeutic targets
Park J, Shin EJ, Kim TH, et al. (2024). Archives of Pharmacal Research.
Summary
A review of nicotinamide N-methyltransferase, the enzyme 5-amino-1MQ inhibits. It describes the enzyme as a link between cellular metabolism and epigenetic regulation, methylating nicotinamide using the body's universal methyl donor and so connecting one-carbon metabolism to NAD+ levels. Expression and activity differ substantially between tissues, and the review surveys the enzyme's reported roles across cancer, liver disease, obesity, diabetes, brain, lung, cardiovascular and kidney conditions. Useful for understanding why inhibiting it is being investigated, and why effects would not be confined to fat tissue.