Salvage of Sildenafil Failures With Bremelanotide: A Randomized, Double-Blind, Placebo Controlled Study
Safarinejad MR, Hosseini SY (2008). Journal of Urology.
Summary
A randomised double-blind placebo-controlled trial of intranasal bremelanotide in men with erectile dysfunction who had not responded to sildenafil. About a third of the bremelanotide group showed a positive clinical result against under a tenth on placebo, with higher reported intercourse satisfaction, and more drug-related adverse effects. The authors call it a possible alternative treatment and say further work on dose and regimen is needed to draw conclusions. This intranasal line of development was later discontinued; the approved product is a subcutaneous injection for a different indication in women.