Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models
Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F (2022). ACS Chemical Neuroscience.
Summary
A laboratory chemistry study of how semax interacts with amyloid beta, the protein that aggregates in Alzheimer's disease, in the presence of copper ions. Using fluorescence, calorimetry and cell viability assays in artificial membrane models, the authors report that semax both prevents the amyloid beta and copper complex forming and reduces aggregation and toxicity, particularly when copper is present. Work in artificial systems; it says nothing about what happens in a living brain.