Study of interactions between DNA and tetrapeptides using methods of molecular mechanics
Tarnovskaya SI, Yakutseni PP, Khavinson VKh (2014). Bulletin of Experimental Biology and Medicine.
Summary
A molecular-modelling study of how the tetrapeptide Lys-Glu-Asp-Trp (pancragen) might bind DNA. The simulations suggest the peptide can sit in both the minor and major groove of the double helix, with major-groove binding depending on the sequences of both peptide and DNA, and propose GGCAG as a candidate binding site. Entirely computational; no experimental binding data are reported in the abstract.