Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration
Wilton P, Chardet Y, Danielson K, et al. (1993). Acta Paediatrica.
Summary
A pharmacokinetic study in 30 healthy men establishing what the peptide does to growth hormone release and how long it lasts. Intravenous administration produced a measurable growth hormone release even at the lowest amount tested, with the response reaching a ceiling above a certain level; the peptide itself cleared quickly while growth hormone stayed elevated for about three hours. Absorbed through the nose, only 3 to 5 percent reached the bloodstream, so a far larger nasal amount was needed for the same effect. Healthy volunteers, single administrations.