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Peptides / Semax / United States

Semax in the United States

Legal status, what it is, and the listed suppliers in the United States that list it.

Legal status in the United States

Not an approved medicine.

As understood at 2026-09-22. Verify with the FDA.

What Semax is

Semax is a synthetic seven-amino-acid peptide built from a fragment of ACTH, the adrenocorticotropic hormone, with a three-amino-acid tail added to slow its breakdown. It was developed in Russia, where it is used clinically in stroke care; the clinical studies below were run there. It is not an approved medicine in the UK, US or Australia.

Full Semax page: targets and research →

Listed suppliers in the United States

9 of the 10 suppliers we list in the United States list Semax. Listed, not endorsed: each row is the supplier’s own stated terms.

American Peptides United States Products are sold for Research Use Only and not for Human Consumption. Not for human or veterinary use. Core Peptides United States Products are for laboratory, research or analytical purposes only, and are not for human consumption. Direct Peptides United States All products are sold strictly for laboratory research use only and are not for human or animal consumption. Direct Peptides is a chemical supplier, not a compounding pharmacy or 503A/503B facility. HEEZ Research United States All products are for laboratory developmental research use only. Products are not for human consumption. HEEZ Research is a chemical supplier. Licensed Peptides United States Supplied strictly for laboratory research use only. Not intended for human consumption, veterinary use, therapeutic applications, or diagnostic use. No dosing instructions are provided. Nationwide Peptides United States For Research Use Only. Products are not intended for human or animal consumption, ingestion, injection, or any form of administration. Peak Lab Peptides United States All products on this site are for research and development use only. Products are not for human consumption of any kind. Protide Health United States All products are supplied for laboratory research only and are not for human or animal consumption, medical use, veterinary use, or any therapeutic, diagnostic, or clinical purpose. Sigma Compounds United States Products are for research and development purposes only and are not for human consumption.

Clinical Research

The efficacy of semax in the treatment of patients at different stages of ischemic stroke
Gusev EI, Martynov MY, Kostenko EV, et al. (2018). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. human 110 people after ischaemic stroke (43 men, 67 women, mean age 58), split by early or late rehabilitation and by whether semax was given
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
Medvedeva EV, Dmitrieva VG, Povarova OV, et al. (2014). BMC Genomics. animal rats with permanent middle cerebral artery occlusion, cortex sampled at 3 and 24 hours
Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice
Liu R, Chen Y, Huang H, et al. (2025). British Journal of Pharmacology. animal female C57BL/6 mice with induced spinal cord injury, plus a PC12 cell neuroinflammation model
Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models
Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F (2022). ACS Chemical Neuroscience. in-vitro artificial membrane models and cell viability assays; no animals or people