Peptides / TB-500 / United States

TB-500 in the United States

Legal status, what it is, and the listed suppliers in the United States that list it.

Legal status in the United States

Not an approved medicine.

As understood at 2026-09-22. Verify with the FDA.

What TB-500 is

TB-500 is a synthetic peptide corresponding to a fragment of thymosin beta-4, a naturally occurring 43-amino-acid protein involved in regulating actin, a building block of cell structure. The published research below is on the full protein, not the fragment that suppliers sell under the name TB-500.

Full TB-500 page: targets and research →

Listed suppliers in the United States

10 of the 10 suppliers we list in the United States list TB-500. Listed, not endorsed: each row is the supplier’s own stated terms.

American Peptides United States Products are sold for Research Use Only and not for Human Consumption. Not for human or veterinary use. BioLongevity Labs United States All products are manufactured for research use only. Research Use Only products sold here are intended solely for laboratory research. Core Peptides United States Products are for laboratory, research or analytical purposes only, and are not for human consumption. Direct Peptides United States All products are sold strictly for laboratory research use only and are not for human or animal consumption. Direct Peptides is a chemical supplier, not a compounding pharmacy or 503A/503B facility. HEEZ Research United States All products are for laboratory developmental research use only. Products are not for human consumption. HEEZ Research is a chemical supplier. Licensed Peptides United States Supplied strictly for laboratory research use only. Not intended for human consumption, veterinary use, therapeutic applications, or diagnostic use. No dosing instructions are provided. Nationwide Peptides United States For Research Use Only. Products are not intended for human or animal consumption, ingestion, injection, or any form of administration. Peak Lab Peptides United States All products on this site are for research and development use only. Products are not for human consumption of any kind. Protide Health United States All products are supplied for laboratory research only and are not for human or animal consumption, medical use, veterinary use, or any therapeutic, diagnostic, or clinical purpose. Sigma Compounds United States Products are for research and development purposes only and are not for human consumption.

Clinical Research

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Bock-Marquette I, Saxena A, White MD, et al. (2004). Nature. animal embryonic and postnatal cardiomyocytes in culture, then mice after coronary artery ligation
Thymosin beta 4 and the eye: the journey from bench to bedside
Sosne G (2018). Expert Opinion on Biological Therapy. review n/a (narrative review by an investigator in the field)
Thymosin β4: actin-sequestering protein moonlights to repair injured tissues
Goldstein AL, Hannappel E, Kleinman HK (2005). Trends in Molecular Medicine. review n/a (review)