Development of Long-Acting Teriparatide Analogues through Iterative Peptide Scanning and Site-Specific Modification by Serine/Threonine Ligation
Liu B, Song K, Sui H, et al. (2026). Journal of Medicinal Chemistry.
Summary
A laboratory paper on longer-acting analogues of teriparatide, an approved osteoporosis medicine. Researchers at Shandong University and the Shandong Academy of Pharmaceutical Sciences used iterative peptide scanning and serine/threonine ligation to attach fatty acids at chosen sites on the peptide. Of 12 lipidated analogues, four (compounds 54, 55, 62 and 63) kept anti-osteoporotic activity in cell assays and in animals close to that of native teriparatide. Compound 62 was the most effective of the four, and the authors report significantly enhanced serum stability for it. The abstract gives no numeric figure for that stability, and it does not name the animal species or how many animals were used. This is laboratory and animal work, including cell assays, not a human trial. Published online on 16 October 2026, in the 12 November 2026 issue.