peptidefix

Cagrilintide

Also: NNC0174-0833, CagriSema (with semaglutide)

Metabolic & weight
Legal status United KingdomNot approvedUnited StatesNot approvedAustraliaNot approved
Research on peptidefix

4 papers: 2 human studies, 2 animal studies.

Listed suppliers United Kingdom5United States6Australia4 Europe2
Checked 2026-11-03

Legal status as understood on this date. Listed, not endorsed. How we list.

Summary

Cagrilintide is a long-acting synthetic analogue of amylin, a 37-amino-acid hormone released alongside insulin that slows stomach emptying and signals fullness. Developed by Novo Nordisk, it is mostly studied in combination with semaglutide under the name CagriSema. It is an investigational drug and not yet licensed anywhere.

What it targets

Cagrilintide acts on amylin and calcitonin receptors. Two phase 3 trials of the cagrilintide-semaglutide combination reported mean body-weight reductions of about 20% in adults with obesity without diabetes (n=3,417) and about 14% in adults with obesity and type 2 diabetes (n=1,206) over 68 weeks, against about 3% with placebo; gastrointestinal adverse events were common but mostly mild to moderate. In diet-induced obese rats, combining cagrilintide with retatrutide lowered weight and food intake more than either alone. The phase 3 data are for the combination, not cagrilintide by itself.

body weight with semaglutide (two phase 3 trials)glycaemic control in type 2 diabetes (phase 3, with semaglutide)combination with retatrutide (rats)

Clinical Research

Continued CagriSema treatment preserves weight loss by reducing energy intake and maintaining energy expenditure in rats
Petersen LM, Knop FK, le Roux CW, et al. (2026). Molecular Metabolism. animal male diet-induced obese rats; six weeks of treatment, with vehicle and calorie-restriction comparators
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity
Garvey WT, Blüher M, Osorto Contreras CK, et al. (REDEFINE 1 Study Group) (2025). New England Journal of Medicine. human adults with overweight or obesity, without diabetes, phase 3a, n=3417
Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes
Davies MJ, Bajaj HS, Broholm C, et al. (REDEFINE 2 Study Group) (2025). New England Journal of Medicine. human adults with overweight or obesity and type 2 diabetes, phase 3a, n=1206
Cagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats
Petersen J, Merrild C, Holm SK, et al. (2026). Nature Metabolism. animal diet-induced obese male rats

All research on Cagrilintide →

Suppliers stocking Cagrilintide

17 of the 49 listed suppliers. Each row opens its full listing.

American Peptides United States Products are sold for Research Use Only and not for Human Consumption. Not for human or veterinary use. Au Peptide Labs Australia For laboratory research use only. Not for human consumption. Aussie Peptides Australia Research use only. Statements have not been evaluated by the TGA. We do not ship internationally at this time. Australian Peptide Site Australia Intended for laboratory and scientific research use only. Australian Research Peptides Australia All products sold by Australian Research Peptides are supplied for in vitro research purposes only — not for human or animal consumption, and not drugs, foods, cosmetics or dietary supplements. Bluewell Peptides United Kingdom All Bluewell products are supplied strictly for laboratory research use only. They are not intended for human consumption, medical use, therapeutic use, diagnostic use, or veterinary use. British Peptide Labs United Kingdom For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment. Direct Peptides United States All products are sold strictly for laboratory research use only and are not for human or animal consumption. Direct Peptides is a chemical supplier, not a compounding pharmacy or 503A/503B facility. Eurolabs Peptides Germany For research purposes only. Not for human consumption. Licensed Peptides United States Supplied strictly for laboratory research use only. Not intended for human consumption, veterinary use, therapeutic applications, or diagnostic use. No dosing instructions are provided. Midshire Labs United Kingdom All Midshire Labs products are sold strictly for research purposes only. They are not intended for human consumption, medical, veterinary, or diagnostic use. Nationwide Peptides United States For Research Use Only. Products are not intended for human or animal consumption, ingestion, injection, or any form of administration. Peak Lab Peptides United States All products on this site are for research and development use only. Products are not for human consumption of any kind. Protide Health United States All products are supplied for laboratory research only and are not for human or animal consumption, medical use, veterinary use, or any therapeutic, diagnostic, or clinical purpose. Research Peptide United Kingdom Supplied strictly for research and laboratory use only and not for human or veterinary consumption. Research Peptides Europe Ireland Lyophilised peptides are for research / laboratory use only — not for human use. The Peptide Company United Kingdom Supplied strictly for laboratory research purposes only. Not intended for human consumption, medical use or self-administration.