BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence
Demirtaş H (2026). International Journal of Molecular Sciences.
Summary
A single-author critical review of preclinical rodent studies of BPC 157 in ischemia-reperfusion injury models. It examines oxidative stress, endothelial and nitric oxide responses, inflammation and cell death across organs. Reported findings include reduced oxidative injury, altered vascular responses and protective effects in skeletal muscle, intestine, liver and hippocampus models. The author notes the evidence is heterogeneous, with short observation periods and single-dose designs, and that it is hypothesis-generating rather than an established therapy. No human data are reviewed.