peptidefix

BPC-157

Also: Body Protection Compound-157, Pentadecapeptide BPC 157

Healing & recovery
Legal status United KingdomNot approvedUnited StatesNot approvedAustraliaPrescription only
Research on peptidefix

13 papers: 3 human studies, 2 animal studies, 3 cell studies, 4 reviews or preprints.

Listed suppliers United Kingdom16United States11Australia11 Europe10
Checked 2026-11-03

Legal status as understood on this date. Listed, not endorsed. How we list.

Summary

BPC-157 is a synthetic peptide of 15 amino acids. Its sequence is derived from a protein found in human gastric juice. It has been studied mainly in animal models, with a large share of the published work coming from a single research group in Croatia, and a 2025 review written for musculoskeletal clinicians notes how widely available the compound has become relative to the evidence behind it.

Guides: BPC-157 vs TB-500 · Is BPC-157 legal in the UK? · 503A vs 503B · Research use only. All guides.

What it targets

Reviews describe BPC-157 as acting through several overlapping pathways, including VEGFR2 and nitric oxide synthesis via the Akt-eNOS axis, and engaging ERK1/2 signalling, with reported effects on blood vessel formation, fibroblast activity and neuromuscular stabilisation, particularly in poorly vascularised tissue such as tendon. A 2026 systematic review screened 630 records down to 64 studies, of which 52 were preclinical and 12 were early human or observational reports, and concluded that the preclinical evidence is small in volume and varied in quality while the human data is limited to small safety-oriented reports. A laboratory study of rat tendon explants and cultured tendon cells reported increased tissue outgrowth, improved cell survival under oxidative stress and increased cell migration.

tendon healing (cell and explant studies)gut lining and the gut-brain axis (systematic review of 64 studies)blood vessel formation (proposed mechanism in reviews)musculoskeletal healing (narrative review, evidence assessed as limited)

Clinical Research

Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury
Yildirim AK, Demirtas H, Ozer A, Arslan M (2026). Scientific Reports. animal 24 male Wistar rats in four groups of six
BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1
Zhang J, Liu M, Ou H, et al. (2026). Cell Communication and Signaling. in-vitro Laboratory cell and biochemical assays (endothelial cells)
Endothelium-dependent nitric oxide-mediated vasorelaxant effects of BPC 157 in human internal mammary artery
Yildirim AK, Dastan AO, Demeli Ertus M, et al. (2026). Journal of Clinical Medicine. in-vitro Artery rings from 12 patients undergoing bypass surgery, ex vivo
Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: a histopathological and biomechanical study
Bicer O, Adanir O, Guleryuz Y, et al. (2026). Joint Diseases and Related Surgery. animal 32 male Sprague-Dawley rats, four groups of eight
BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence
Demirtaş H (2026). International Journal of Molecular Sciences. review n/a (review of rodent studies, literature search to 24 June 2026)
Former company and directors behind BioV8 to face court for alleged unlawful advertising of peptides
Therapeutic Goods Administration (Australia) (2026). Therapeutic Goods Administration. regulatory Australia, TGA media release on Federal Court proceedings
Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study
Lee E, Burgess K (2025). Altern Ther Health Med. human 2 healthy adults; IRB-approved uncontrolled safety pilot with baseline and serial measurements
Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study
Lee E, Walker C, Ayadi B (2024). Altern Ther Health Med. human 12 women (mean age 58.3) with interstitial cystitis that had not responded to conventional therapy; open-label, uncontrolled pilot
Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain
Lee E, Padgett B (2021). Altern Ther Health Med. human 17 adults with knee pain, retrospective chart review with telephone follow-up, no control group
BPC-157 and the gut–brain axis: emerging links between cytoprotection and neuroregeneration
Pietrzyk B, Waluga M (2026). Annales Academiae Medicae Silesiensis. review n/a (systematic review of 64 studies: 52 preclinical, 12 early human or observational)
Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing
McGuire FP, Martinez R, Lenz A, et al. (2025). Current Reviews in Musculoskeletal Medicine. review n/a (scoping review of preclinical and clinical data)
Brain-gut axis and pentadecapeptide BPC 157: theoretical and practical implications
Sikiric P, Seiwerth S, Rucman R, et al. (2016). Current Neuropharmacology. review n/a (review)
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH (2011). Journal of Applied Physiology. in-vitro rat tendon explants and cultured tendon cells

All research on BPC-157 →

Suppliers stocking BPC-157

48 of the 49 listed suppliers. Each row opens its full listing.

Au Peptide Labs Australia For laboratory research use only. Not for human consumption. Aussie Peptides Australia Research use only. Statements have not been evaluated by the TGA. We do not ship internationally at this time. Australian Peptide Site Australia Intended for laboratory and scientific research use only. Australian Research Peptides Australia All products sold by Australian Research Peptides are supplied for in vitro research purposes only — not for human or animal consumption, and not drugs, foods, cosmetics or dietary supplements. Baltic BioLabs Lithuania For laboratory research only, not for human or veterinary use. Baltic Peptides Lithuania All products are supplied strictly for laboratory research use only. Not for human or veterinary use. BioLongevity Labs United States All products are manufactured for research use only. Research Use Only products sold here are intended solely for laboratory research. Bluewell Peptides United Kingdom All Bluewell products are supplied strictly for laboratory research use only. They are not intended for human consumption, medical use, therapeutic use, diagnostic use, or veterinary use. British Peptide Labs United Kingdom For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment. Buy Australia Peptides Australia Supplied strictly for laboratory research purposes only. Not for human or veterinary consumption. CertaPeptides Romania All CertaPeptides products are sold exclusively for in-vitro laboratory research. They are not approved for human consumption, veterinary use, therapeutic applications… Core Peptides United States Products are for laboratory, research or analytical purposes only, and are not for human consumption. Direct Peptides United States All products are sold strictly for laboratory research use only and are not for human or animal consumption. Direct Peptides is a chemical supplier, not a compounding pharmacy or 503A/503B facility. Dutch Peptides Netherlands Research Use Only — not for human consumption. ELYVERA Austria All products are for research purposes only. Eurolabs Peptides Germany For research purposes only. Not for human consumption. Global Peptides Australia Unmodified peptides are sold for research use only. HEEZ Research United States All products are for laboratory developmental research use only. Products are not for human consumption. HEEZ Research is a chemical supplier. Imperial Peptides UK United Kingdom In Vitro Research Use Only. Not for human or veterinary consumption. Licensed Peptides United States Supplied strictly for laboratory research use only. Not intended for human consumption, veterinary use, therapeutic applications, or diagnostic use. No dosing instructions are provided. Midshire Labs United Kingdom All Midshire Labs products are sold strictly for research purposes only. They are not intended for human consumption, medical, veterinary, or diagnostic use. Nationwide Peptides United States For Research Use Only. Products are not intended for human or animal consumption, ingestion, injection, or any form of administration. Next Gen Peptides Australia Not for human consumption. Novacell Peptides Estonia All products of NCBL Sciences OÜ / NovaCell Peptides are intended exclusively for laboratory-based in-vitro research. Not for human or veterinary use, not a medicinal product, food or cosmetic. Nupex United Kingdom Products sold on nupex.co.uk are for research purposes only and are not for human or veterinary use. Particle Peptides Slovakia Goods offered by the Company in the E-shop for purposes of scientific research and development (in vitro). Peak Lab Peptides United States All products on this site are for research and development use only. Products are not for human consumption of any kind. Pept Australia Products sold by Pept are intended for laboratory research purposes only and are not approved for human consumption. Peptide Solutions Australia Australia All products are supplied strictly for research purposes only. They are not intended for human consumption, animal consumption, medical use, diagnostic use, therapeutic use. Peptides Lab UK United Kingdom Strictly intended for laboratory research use only. Not for human or veterinary consumption. PeptidesUK United Kingdom For research use only. Peptopia Australia For in vitro research use only. Not for human or veterinary consumption. Not evaluated or approved by the TGA. Precision Research UK United Kingdom For laboratory and research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use. Prism Labs United States All products sold by Prism Labs are intended strictly for in-vitro research, laboratory experimentation, and educational purposes. Products are not intended for human or veterinary use. Protide Health United States All products are supplied for laboratory research only and are not for human or animal consumption, medical use, veterinary use, or any therapeutic, diagnostic, or clinical purpose. Pulse Peptides Cyprus Products are not intended for administration to humans or animals and are not presented as having any medical, diagnostic, therapeutic, or clinical purpose. Pure Peptides UK United Kingdom All products are for research use only. Research Peptide United Kingdom Supplied strictly for research and laboratory use only and not for human or veterinary consumption. Research Peptides Europe Ireland Lyophilised peptides are for research / laboratory use only — not for human use. Sigma Compounds United States Products are for research and development purposes only and are not for human consumption. Stratford Peptides United Kingdom Products sold are for research purposes only and are not for human or veterinary use. Synapse Peptides Australia Australia All products are supplied strictly for research purposes only and are not intended for human or veterinary use. The Peptide Company United Kingdom Supplied strictly for laboratory research purposes only. Not intended for human consumption, medical use or self-administration. ThePeptideCode United Kingdom All products on this website are supplied strictly as research materials for laboratory and research use only — not for human or veterinary use. Tide Labs United Kingdom For laboratory research use only. Not for human or veterinary use. UK Peptides United Kingdom All products are sold exclusively for in-vitro research. They are not for human or veterinary use. Xeno Peptides United States All products are for laboratory and research use only — not for human consumption or clinical application. XL Peptides United Kingdom All products are exclusively sold for research purposes. They are not intended for human use, therapeutic, diagnostic, or clinical application.