peptidefix

TB-500

Also: Thymosin beta-4 fragment, T-beta-4 (17-23)

Healing & recovery
Legal status United KingdomNot approvedUnited StatesNot approvedAustraliaPrescription only
Research on peptidefix

6 papers: 3 animal studies, 1 cell study, 2 reviews or preprints.

Listed suppliers United Kingdom16United States12Australia9 Europe7
Checked 2026-11-03

Legal status as understood on this date. Listed, not endorsed. How we list.

Summary

TB-500 is a synthetic peptide corresponding to a fragment of thymosin beta-4, a naturally occurring 43-amino-acid protein involved in regulating actin, a building block of cell structure. The published research below is on the full protein, not the fragment that suppliers sell under the name TB-500.

Guides: BPC-157 vs TB-500 · Research use only. All guides.

What it targets

A 2004 study in Nature reported that thymosin beta-4 promotes migration of heart muscle and blood vessel cells and improves their survival in culture, forming a complex with PINCH and integrin-linked kinase that activates the survival kinase Akt; in mice whose coronary artery had been tied off, treatment improved early heart muscle cell survival and cardiac function. The protein also reached late-stage human trials in eye medicine: a 2018 account by one of the investigators reports phase 3 trials in dry eye and neurotrophic keratopathy under way at that time. A 2005 review sets out its role in sequestering actin and the tissue-repair properties that follow. No study of the TB-500 fragment itself appears in the literature reviewed for this page.

cardiac cell survival and repair after induced heart attack in mice (full protein)corneal wound healing and dry eye (phase 3 programme, full protein)actin regulation and tissue repair (review)

Clinical Research

Adjunctive recombinant human thymosin β4 therapy improves antibacterial outcomes against Staphylococcus aureus
Banga L, Patel D, Shawky M, et al. (2026). Microbiology Spectrum. in-vitro in vitro bacterial culture; recombinant human thymosin beta-4 (the full protein, not the TB-500 fragment); not tested in animals or people
Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: a histopathological and biomechanical study
Bicer O, Adanir O, Guleryuz Y, et al. (2026). Joint Diseases and Related Surgery. animal 32 male Sprague-Dawley rats, four groups of eight
Reparative outcomes in corneal infection: linking adjunctive Tβ4 treatment to nerve regeneration and visual function
Ebrahim AS, Liu L, Carion TW, et al. (2026). Investigative Ophthalmology & Visual Science. animal C57BL/6 mice with Pseudomonas keratitis; thymosin beta-4 with ciprofloxacin vs each alone and vehicle
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Bock-Marquette I, Saxena A, White MD, et al. (2004). Nature. animal embryonic and postnatal cardiomyocytes in culture, then mice after coronary artery ligation
Thymosin beta 4 and the eye: the journey from bench to bedside
Sosne G (2018). Expert Opinion on Biological Therapy. review n/a (narrative review by an investigator in the field)
Thymosin β4: actin-sequestering protein moonlights to repair injured tissues
Goldstein AL, Hannappel E, Kleinman HK (2005). Trends in Molecular Medicine. review n/a (review)

All research on TB-500 →

Suppliers stocking TB-500

44 of the 49 listed suppliers. Each row opens its full listing.

American Peptides United States Products are sold for Research Use Only and not for Human Consumption. Not for human or veterinary use. Au Peptide Labs Australia For laboratory research use only. Not for human consumption. Aussie Peptides Australia Research use only. Statements have not been evaluated by the TGA. We do not ship internationally at this time. Australian Peptide Site Australia Intended for laboratory and scientific research use only. Australian Research Peptides Australia All products sold by Australian Research Peptides are supplied for in vitro research purposes only — not for human or animal consumption, and not drugs, foods, cosmetics or dietary supplements. Baltic BioLabs Lithuania For laboratory research only, not for human or veterinary use. Baltic Peptides Lithuania All products are supplied strictly for laboratory research use only. Not for human or veterinary use. BioLongevity Labs United States All products are manufactured for research use only. Research Use Only products sold here are intended solely for laboratory research. Bluewell Peptides United Kingdom All Bluewell products are supplied strictly for laboratory research use only. They are not intended for human consumption, medical use, therapeutic use, diagnostic use, or veterinary use. British Peptide Labs United Kingdom For research use only. Not for human or veterinary use. Sold strictly for in-vitro laboratory research; not for diagnosis or treatment. Buy Australia Peptides Australia Supplied strictly for laboratory research purposes only. Not for human or veterinary consumption. Core Peptides United States Products are for laboratory, research or analytical purposes only, and are not for human consumption. Direct Peptides United States All products are sold strictly for laboratory research use only and are not for human or animal consumption. Direct Peptides is a chemical supplier, not a compounding pharmacy or 503A/503B facility. Eurolabs Peptides Germany For research purposes only. Not for human consumption. Global Peptides Australia Unmodified peptides are sold for research use only. HEEZ Research United States All products are for laboratory developmental research use only. Products are not for human consumption. HEEZ Research is a chemical supplier. Imperial Peptides UK United Kingdom In Vitro Research Use Only. Not for human or veterinary consumption. Licensed Peptides United States Supplied strictly for laboratory research use only. Not intended for human consumption, veterinary use, therapeutic applications, or diagnostic use. No dosing instructions are provided. Midshire Labs United Kingdom All Midshire Labs products are sold strictly for research purposes only. They are not intended for human consumption, medical, veterinary, or diagnostic use. Nationwide Peptides United States For Research Use Only. Products are not intended for human or animal consumption, ingestion, injection, or any form of administration. Next Gen Peptides Australia Not for human consumption. Novacell Peptides Estonia All products of NCBL Sciences OÜ / NovaCell Peptides are intended exclusively for laboratory-based in-vitro research. Not for human or veterinary use, not a medicinal product, food or cosmetic. Nupex United Kingdom Products sold on nupex.co.uk are for research purposes only and are not for human or veterinary use. Particle Peptides Slovakia Goods offered by the Company in the E-shop for purposes of scientific research and development (in vitro). Peak Lab Peptides United States All products on this site are for research and development use only. Products are not for human consumption of any kind. Peptides Lab UK United Kingdom Strictly intended for laboratory research use only. Not for human or veterinary consumption. PeptidesUK United Kingdom For research use only. Peptopia Australia For in vitro research use only. Not for human or veterinary consumption. Not evaluated or approved by the TGA. Precision Research UK United Kingdom For laboratory and research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use. Prism Labs United States All products sold by Prism Labs are intended strictly for in-vitro research, laboratory experimentation, and educational purposes. Products are not intended for human or veterinary use. Protide Health United States All products are supplied for laboratory research only and are not for human or animal consumption, medical use, veterinary use, or any therapeutic, diagnostic, or clinical purpose. Pulse Peptides Cyprus Products are not intended for administration to humans or animals and are not presented as having any medical, diagnostic, therapeutic, or clinical purpose. Pure Peptides UK United Kingdom All products are for research use only. Research Peptide United Kingdom Supplied strictly for research and laboratory use only and not for human or veterinary consumption. Research Peptides Europe Ireland Lyophilised peptides are for research / laboratory use only — not for human use. Sigma Compounds United States Products are for research and development purposes only and are not for human consumption. Stratford Peptides United Kingdom Products sold are for research purposes only and are not for human or veterinary use. Synapse Peptides Australia Australia All products are supplied strictly for research purposes only and are not intended for human or veterinary use. The Peptide Company United Kingdom Supplied strictly for laboratory research purposes only. Not intended for human consumption, medical use or self-administration. ThePeptideCode United Kingdom All products on this website are supplied strictly as research materials for laboratory and research use only — not for human or veterinary use. Tide Labs United Kingdom For laboratory research use only. Not for human or veterinary use. UK Peptides United Kingdom All products are sold exclusively for in-vitro research. They are not for human or veterinary use. Xeno Peptides United States All products are for laboratory and research use only — not for human consumption or clinical application. XL Peptides United Kingdom All products are exclusively sold for research purposes. They are not intended for human use, therapeutic, diagnostic, or clinical application.